This subline investigates the pathophysiological mechanisms responsible for ischemia-reperfusion injury and regeneration. Therapeutical repair of ischemia/reperfusion injury is being studied by the use of surgical
procedures (ischemic preconditioning) or the promotion of endogenous regeneration.
Using experimental models including hypoxia, renal ischemia, hepatic warm ischemia/reperfusion models (hepatectomy) and orthotopic liver transplantation (using complete and reduced grafts), we are identifying regenerative genes involved in the regeneration process. Cell therapy with genetic manipulation of the identified genes allows us to enhance repair and tissue regeneration. Our goal is to find novel therapeutic targets and novel manoeuvres to promote restoration after damage.
We aim to repair ischemia/reperfusion injury by the use of surgical procedures (ischemic preconditioning) or the promotion of endogenous regeneration through regenerative cell therapy