Mechanisms of Damage and Recovery in disorders associated with abdominal organs

Responsible: 

Georgina Hotter Corripio

Researcher

This research line investigates the molecular mechanisms responsible for damage and regeneration in pathologies associated with abdominal organs. Our goal is to identify new therapeutic strategies for their prevention or that to enhance the regeneration of damaged tissue.

In this regard, some of the molecular processes involved in ischemia-reperfusion injury and in liver regeneration associated with transplantation have been identified. In addition, the use of different drugs as a potential tool for the prevention of the deleterious effects of ischemia-reperfusion injury has been highlighted. Concerning renal ischemia-reperfusion associated with acute renal failure, the efficacy of cell therapies based on promoting renal regeneration with cells of the immune system has been validated. Currently, and taking into account that the pancreas is a highly susceptible organ, we have also focused our interest on the study of new therapeutic targets for the protection of pancreatic grafts.

Our research work combines the use of cell models and primary cell cultures with in vivo and ex vivo animal models that reproduce different human diseases, as well as the development of effective therapies to promote tissue regeneration. Our team is also affiliated with the CIBER-BBN (Center for Biomedical Research in the Network of Bioengineering, Biomaterials and Nanomedicine) and the CIBEREHD (Center for Biomedical Research in the Network of Diseases Hepatic and Digestive).