The oligonucleotide, designed to act only on dopaminergic and noradrenergic neurons, reduces the production and accumulation of the mutant alpha-synuclein protein, a key protein in the development of Parkinson's disease
The work is led by the Barcelona Biomedical Research Institute of the CSIC and IDIBAPS
The study recently published in Molecular Neurodegeneration journal with Vicente Roca as the first author and directed by
They have participated in the 4th edition of an international consensus on the interpretation, mechanisms and various multidisciplinary aspects of autophagy.
An international team of multidisciplinary researchers has identified one of the molecular mechanisms underlying cardiac alternans, an alteration of the heart rhythm that facilitates the induction of ventricular fibrillation, a potentially fatal arrhythmia. Furthermore, they show that people with loss of ryanodine receptor (RyR) function are prone to induction of ventricular fibrillation and sudden death caused by cardiac alternans.
The importance of including women in all sciences at all levels
El CHC és el càncer de fetge més comú i la fase final de les malalties hepàtiques cròniques de diverses etiologies, com l'hepatitis viral, la malaltia hepàtica alcohòlica o la esteatohepatitis no alcohòlica (EHNA). Es preveu que el CHC per EHNA augmenti a tot el món a causa de la seva associació amb l'epidèmia d'obesitat i diabetis de tipus 2.
A recent study published in GUT, co-directed by Ki-Up Lee of the University of Ulsan, South Korea and José C. Fernandez-Checa, leader of the group "Mitochondrial regulation of cell death" at the IIBB, describes a new role for the Sphingomyelinase synthase 1 (SMS1) in hepatocellular death associated with the inflammation characteristic of nonalcoholic steatohepatitis, called pyroptosis.