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Regulació Mitocondrial de la Mort Cel·lular

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky DJ;Abdel-Aziz AK;Abdelfatah S;Abdellatif M;Sanchez-Alcazar JA;Arevalo M.A.;Alonso A.;Beltran J.S.D.O;Boya P.;Casas J.;Collel A.;Coll N.S.;Crespo J.L.;Cuadrado A.;Duran R.V.;Escalante R.;Fernandez-Checa J.C.;Figueras;Moles A.;Perez-Perez M.E.;Sanz,
2021

Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

Fernandez-Checa JC, Bagnaninchi P, Ye H, Sancho-Bru P, Falcon-Perez JM, Royo F, Garcia-Ruiz C, Konu O, Miranda J, Lunov O, Dejneka A, Elfick A, McDonald A, Sullivan GJ, Aithal GP, Lucena MI, Andrade RJ, Fromenty B, Kranendonk M, Cubero FJ, Nelson LJ.,
2021

NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake

Alari-Pahissa E, Ataya M, Moraitis I, Campos-Ruiz M, Altadill M, Muntasell A, Moles A, López-Botet M,
2021

Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCC

Ribas V, de la Rosa LC, Robles D, Núñez S, Segalés P, Insausti-Urkia N, Solsona-Vilarrasa E, Fernández-Checa JC, García-Ruiz C. ,
2021

Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation

Torres S, Solsona-Vilarrasa E, Nuñez S, Matías N, Insausti-Urkia N, Castro F, Casasempere M, Fabriás G, Casas J, Enrich C, Fernández-Checa JC, Garcia-Ruiz C. Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disea,
2021

STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway

Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, Baulies A, Nuñez S, Monte MJ, Marin JJG, Baila-Rueda L, Cenarro A, Civeira F, Fuster J, Garcia-Valdecasas JC, Ferrer J, Karin M, Ribas V, Fernandez-Checa JC.,
2021

GDF11 restricts aberrant lipogenesis and changes in mitochondrial structure and function in human hepatocellular carcinoma cells

Hernandez S, Simoni-Nieves A, Gerardo-Ramírez M, Torres S, Fucho R, Gonzalez J, Castellanos-Tapia L, Hernández-Pando R, Tejero-Barrera E, Bucio L, Souza V, Miranda-Labra R, Fernández-Checa JC, Marquardt JU, Gomez-Quiroz LE, García-Ruiz C, Gutiérrez-Ruiz M,
2021

Disrupted Mitochondrial and Metabolic Plasticity Underlie Comorbidity between Age-Related and Degenerative Disorders as Parkinson Disease and Type 2 Diabetes Mellitus

Fucho R, García-Ruiz C, Fernandez-Checa JC et. al.,
2020

Sphingomyelinases and Liver Diseases

Insausti-Urkia N, Solsona-Vilarrasa E, Garcia-Ruiz C, Fernandez-Checa JC.,
2020

Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis.

Eun Hee Koh;Ji Eun Yoon;Myoung Seok Ko;Jaechan Leem;Ji-Young Yun;Chung Hwan Hong;Yun Kyung Cho;Seung Eun Lee;Jung Eun Jang;Ji Yeon Baek Hyun Ju Yoo;Su Jung Kim;Chang Ohk Sung;Joon Seo Lim;Won-Il Jeong;Sung Hoon Back;In-Jeoung Baek;Sandra Torres;Estel Sols,
2020

MITOCHONDRIAL CHOLESTEROL AND CANCER

Garcia-Ruiz C, de la Rosa LC, Ribas V, Fernandez-Checa JC.,
2020

Cholesterol Induces Nrf-2- And HIF-1 α-Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and Fibrosis

Kaminsky-Kolesnikov Y, Rauchbach E, Abu-Halaka D, Hahn M, García-Ruiz C, Fernandez-Checa JC, Madar Z, Tirosh O.,
2020

Cathepsins in the Pathophysiology of Mucopolysaccharidoses: New Perspectives for Therapy

De Pasquale V, Moles A, Pavone LM.,
2020

Editorial: Autophagy and Related Transcription Factors in Liver and Gut Diseases

Eid N, Menon MB, Thomes P, Zeng T, Raimundo N, Fernandez-Checa JC, Wang L, Ito Y, Otsuki Y, Adeghate E.,
2020

STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome

Arenas F, Castro F, Nuñez S, Gay G, Garcia-Ruiz C, Fernandez-Checa JC.,
2020

Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure

Torres S, Baulies A, Insausti-Urkia N, Alarcón-Vila C, Fucho R, Solsona-Vilarrasa E, Núñez S, Robles D, Ribas V, Wakefield L, Grompe M, Lucena MI, Andrade RJ, Win S, Aung TA, Kaplowitz N, García-Ruiz C, Fernández-Checa JC.,
2019

Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes.

Solsona-Vilarrasa E, Fucho R, Torres S, Nuñez S, Nuño-Lámbarri N, Enrich C, García-Ruiz C, Fernández-Checa JC.,
2019

The Effect of Zinc Acexamate on Oxidative Stress, Inflammation and Mitochondria Induced Apoptosis in Rat Model of Renal Warm Ischemia

Hadj Abdallah N, Baulies A, Bouhlel A, Bejaoui M, Zaouali MA, Ben Mimouna S, Messaoudi I, Fernandez-Checa JC, García Ruiz C, Ben Abdennebi H.,
2018

Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

Prieto-Domínguez N, Ordóñez R, Fernández A, Méndez-Blanco C, Baulies A, Garcia-Ruiz C, Fernández-Checa JC, Mauriz JL, González-Gallego J.,
2016

Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice

Nuño-Lámbarri N, Domínguez-Pérez M, Baulies-Domenech A, Monte MJ, Marin JJ, Rosales-Cruz P, Souza V, Miranda RU, Bucio L, Montalvo-Jave EE, Concepción Gutiérrez-Ruiz M, García-Ruiz C, Fernández-Checa JC, Gomez-Quiroz LE,
2016

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