The Biological Mass Spectrometry and Proteomics (BMSP) Research sub-line is the offspring of the former Biological and Structural Mass Spectrometry (EMEB) Unit which in 2007 moved to the Barcelona Autonomous University (UAB) campus in the frame of a CSIC/UAB agreement to constitute the CSIC/UAB Proteomics Laboratory ( http://proteomica.uab.cat ).
We focus on the research and development of methods and technologies directed to the characterization of biological markers in cells tissues and fluids specially those related with pathological processes.
Our research is directed to the discovery of new protein markers in disease. This task implies also a strong dedication to method and technological development mainly in the field of capillary chromatography, mass spectrometry and bioinformatics.
Major Proteomics areas addressed include the characterization of posttranslational modifications, proteome-wide accurate quantitation and de novo protein identification.
In particular, we are focussing on protein phosphorylation in T-Lymphocytes as a model for the study of immunological response. We aim to create a database of T-lymphocyte phosphosites and phosphoproteins and to characterize the proteomic profile after the activation of these cells with different agonists.
We make advances in these studies inmediately available to other projects and to the research community in general though a transparent transfer of metodologies to the CSIC/UAB Proteomics Facility.