In this year's call for La Marató de TV3 dedicated to fighting COVID-19, 229 proposals have been presented, of which 36 have been selected.
Messenger RNA (mRNA) is becoming an increasingly important target for therapeutic intervention. The mRNA molecule transmits information directly from the genome.
Parkinson's disease is the second most common neurodegenerative disease after Alzheimer’s disease and is characterized by a progressive loss of neurons involved in the control of movement.
The oligonucleotide, designed to act only on dopaminergic and noradrenergic neurons, reduces the production and accumulation of the mutant alpha-synuclein protein, a key protein in the development of Parkinson's disease
The work is led by the Barcelona Biomedical Research Institute of the CSIC and IDIBAPS