Offer for Ramón y Cajal 2019 Fellow. Neurobiology

IP Ramon Trullas

Research line: The loss of neuronal synapses is a phenomenon that occurs in the early stages of neurodegenerative disorders such as Alzheimer's disease and is considered a cause of the memory deficits characteristic of this disease. However, the mechanisms responsible for synapse modification during neurodegeneration are not precisely known.

The Neurobiology Unit project starts from the hypothesis that mitochondrial DNA (mtDNA) is a central mechanism in the pathological chain of the synaptic neurodegeneration process. The general objectives of our work are:

1) Identify the molecular mechanisms that cause the modification of synapses in neurodegeneration models and

2) Study the transcription and replication of mitochondrial DNA in genetic models of neurodegenerative diseases.