Dr Anna Moles, group leader, and Paloma Ruiz and Maria Fernández, PhD researchers, of the Tissue Remodeling, Fibrosis and Cancer Group have co-authored a publication lead by Dr Pau Sancho and Dr Raquel Martinez, from IDIBAPS, in Nature Communications.
This work shines new light on hepatic stellate cells commitment and metabolic reprogramming during liver fibrosis. The study underlines the importance of examining cell trajectories during both differentiation and disease. In this work the authors reveal that hepatic stellate cell differentiation and fibrosis mechanisms can be effectively modelled using iPSC-derived cells, thus, enabling the identification of key transcription factors like RORA that regulate cell identity differentiation, and fibrogenesis and can lead to the development of new therapeutic strategies to mitigate fibrosis across multiple tissues.
Martínez García de la Torre, R.A., Vallverdú, J., Xu, Z. et al. Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis. Nat Commun 16, 1489 (2025). https://doi.org/10.1038/s41467-025-56024-4
